Opportunity Information: Apply for PAR 18 925
The National Institutes of Health (NIH) funding opportunity titled "Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18 Clinical Trial Required)" (Funding Opportunity Number PAR-18-925) supports real-world, practice-based research aimed at improving how healthcare systems prevent and treat diabetes and obesity. The central idea is to fund studies that do not just test an intervention in a controlled research environment, but instead evaluate practical strategies that can work inside everyday clinical operations where patients already receive care. Because this is an R18 mechanism and a clinical trial is required, applicants are expected to run a rigorous, intervention-based study that tests an approach designed to change outcomes, not simply observe them.
A key expectation is that projects focus on pragmatic, sustainable improvements to both care processes and patient health outcomes for people who have diabetes or obesity, as well as those at risk for these conditions. The FOA emphasizes interventions that can realistically be maintained over time with the resources and workflows of typical healthcare settings. This means proposed strategies should fit into existing clinical structures, such as care teams, electronic health record workflows, referral pathways, patient outreach systems, or routine visit processes. The healthcare setting cannot be treated as a convenient place to recruit participants while the intervention itself happens outside normal care; instead, the intervention needs to be integrated into the way care is delivered.
Another major theme is dissemination potential. NIH is looking for approaches that are not so unique to one clinic or health system that they cannot be repeated elsewhere. Applicants should design and test strategies that could reasonably be adopted by other healthcare organizations, including those serving different populations or operating with varying resource levels. The practical goal is to produce results that can directly improve healthcare practice and also provide evidence that can inform policy decisions related to diabetes and obesity prevention and management.
The opportunity falls under the discretionary grant category, with a funding activity focus in health and food and nutrition, and it is associated with CFDA number 93.847. A wide range of organizations are eligible to apply, reflecting the intent to reach diverse healthcare environments and communities. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other entities that meet eligibility rules.
The FOA also explicitly highlights additional eligible applicant types that often serve priority or underserved populations, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal government agencies, faith-based or community-based organizations, regional organizations, tribal governments that are not federally recognized, and U.S. territories or possessions. At the same time, it places clear limits on foreign participation: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply; non-U.S. components of U.S. organizations are not eligible; and foreign components, as defined by the NIH Grants Policy Statement, are not allowed. In practical terms, projects must be fully domestic in where the work is conducted and how the applicant organization is structured.
The original closing date listed for this opportunity was February 13, 2020, and the FOA creation date was October 2, 2018. While the summary above captures the intent and the core requirements, applicants typically would still need to consult the full FOA text for details on study design expectations, review criteria, allowable costs, data and safety requirements for the clinical trial component, and any specific NIH institute priorities tied to diabetes and obesity care improvement.Apply for PAR 18 925
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2018-10-02.
- Applicants must submit their applications by 2020-02-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18 Clinical Trial Required)" and the Funding Opportunity Number is PAR-18-925.
What is the main purpose of this funding opportunity?
This NIH opportunity supports real-world, practice-based research in healthcare settings to improve how health systems prevent and treat diabetes and obesity. The focus is on testing practical strategies that work within everyday clinical operations, rather than testing an intervention only in a controlled research environment.
What kind of research approach is NIH looking for here?
NIH is looking for pragmatic research conducted in healthcare settings. That means studies should evaluate interventions in the context of routine care, using typical workflows, staff roles, and operational constraints. The intervention is expected to be embedded in how care is actually delivered, not run as a separate research-only activity.
Does this opportunity require a clinical trial?
Yes. This is an R18 mechanism and a clinical trial is required. Applicants are expected to conduct a rigorous, intervention-based study designed to change outcomes (not simply observe outcomes).
What does it mean that this is an R18 mechanism?
Based on the description provided, the R18 mechanism here is tied to running a rigorous, intervention-based study in real-world healthcare settings, with a required clinical trial component.
Who should benefit from projects funded under this FOA?
Projects are expected to improve care processes and patient health outcomes for people who have diabetes or obesity, as well as people who are at risk for these conditions.
What kinds of outcomes should the funded projects aim to improve?
The FOA emphasizes pragmatic, sustainable improvements to both care processes (how care is delivered) and patient health outcomes related to diabetes and obesity prevention and care.
What does NIH mean by "pragmatic" in this context?
"Pragmatic" means the intervention and study should be designed for real-world use inside healthcare settings. The approach should be realistic to implement and maintain using typical clinical resources and workflows, rather than relying on special research-only infrastructure.
What does "sustainable improvements" mean for this FOA?
Sustainable improvements are strategies that can be maintained over time within ordinary healthcare resources and routine workflows. The FOA favors approaches that health systems could continue after the study ends without requiring unusual staffing, processes, or funding streams that are not typical in practice.
Where should the intervention take place?
The intervention should be integrated into everyday clinical operations where patients already receive care. The healthcare setting should not be used only as a place to recruit participants while the intervention happens outside normal care delivery.
What are examples of clinical structures the intervention could fit into?
The FOA notes that strategies should fit into existing clinical structures such as care teams, electronic health record workflows, referral pathways, patient outreach systems, or routine visit processes.
Is it acceptable to recruit patients in a clinic but deliver the intervention outside routine care?
No. The FOA indicates the healthcare setting cannot be treated as a convenient recruitment site while the intervention itself occurs outside normal care. The intervention should be embedded in the way care is delivered.
How important is dissemination and scalability for this grant?
Dissemination potential is a major theme. NIH is looking for approaches that are not so unique to a single clinic or health system that they cannot be repeated elsewhere. Applicants should aim for strategies that could reasonably be adopted by other healthcare organizations, including those with different populations and resource levels.
What kinds of broader impacts does NIH want from funded projects?
The FOA describes a practical goal of producing results that can directly improve healthcare practice and also generate evidence that can inform policy decisions related to diabetes and obesity prevention and management.
What is the grant category and general focus area?
This opportunity is in the discretionary grant category, with a funding activity focus in health and food and nutrition.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 93.847.
What types of organizations are eligible to apply?
A wide range of organizations are eligible, including: state, county, city, or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities that meet eligibility rules.
Are minority-serving institutions and community-based groups mentioned as eligible?
Yes. The FOA explicitly highlights additional eligible applicants that often serve priority or underserved populations, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, and regional organizations.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly highlighted among eligible applicant types.
Are federal government agencies eligible to apply?
Yes. Eligible federal government agencies are explicitly highlighted as eligible applicant types.
Can foreign organizations apply for this NIH funding opportunity?
No. Non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply.
Can a U.S. organization include non-U.S. components in the application?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed in any form?
No. Foreign components, as defined by the NIH Grants Policy Statement, are not allowed. In practical terms, the project must be fully domestic in where the work is conducted and how the applicant organization is structured.
What was the original closing date for this funding opportunity?
The original closing date listed was February 13, 2020.
When was this FOA created?
The FOA creation date was October 2, 2018.
What should applicants review in the full FOA before applying?
Applicants are expected to consult the full FOA text for details such as study design expectations, review criteria, allowable costs, data and safety requirements for the required clinical trial component, and any NIH institute priorities tied to improving diabetes and obesity prevention and care.
Is this funding aimed at controlled lab-style studies or real-world implementation?
The emphasis is on real-world implementation and evaluation in practice settings. The FOA is designed for research that tests practical strategies inside everyday healthcare operations rather than relying on controlled, research-only environments.
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| Human Pancreas Analysis Program for Type-2 Diabetes (HPAP-T2D) (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 016 Funding Number: RFA DK 18 016 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $2,000,000 |
| Human Pancreas Analysis Program (HPAP) (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 015 Funding Number: RFA DK 18 015 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $30,000,000 |
| Understanding the Glycemic Profile of Pregnancy - Biostatistics Research Center (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 019 Funding Number: RFA DK 18 019 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,500,000 |
| Diabetes Research Centers (P30) Apply for RFA DK 18 020 Funding Number: RFA DK 18 020 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Education Program Grants (R25 Clinical Trial Not Allowed) Apply for PAR 19 030 Funding Number: PAR 19 030 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $100,000 |
| Human Islet Research Network - Consortium on Targeting and Regeneration (HIRN-CTAR) (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 014 Funding Number: RFA DK 18 014 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $550,000 |
| Medical Simulators for Practicing Patient Care Providers Skill Acquisition, Outcomes Assessment and Technology Development (R01 Clinical Trial Not Allowed) Apply for PA 19 065 Funding Number: PA 19 065 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Support for Small Business Innovation Research to Develop New Open and Closed-Loop Automated Technologies for Better Type 1 Diabetes Therapy and Monitoring (SBIR) (R43/R44 Clinical Trial Not Allowed) Apply for RFA DK 18 022 Funding Number: RFA DK 18 022 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $300,000 |
| HEAL Initiative: Integrated Approach to Pain and Opioid Use in Hemodialysis Patients: The Hemodialysis Opioid Prescription Effort (HOPE) Consortium - Clinical Centers (U01 Clinical Trial Required) Apply for RFA DK 18 030 Funding Number: RFA DK 18 030 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed) Apply for PAS 19 105 Funding Number: PAS 19 105 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Human Islet Research Network - Consortium on Modeling Autoimmune Interactions (HIRN-CMAI) (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 013 Funding Number: RFA DK 18 013 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/44 Clinical Trial Not Allowed) Apply for RFA DK 18 023 Funding Number: RFA DK 18 023 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Establishing a Cohort to Clarify Risk and Protective Factors for Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) - Planning Cooperative Agreements (U34 Clinical Trial Not Allowed) Apply for RFA DK 18 007 Funding Number: RFA DK 18 007 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
| Mass Spectrometric Assays for the Reliable and Reproducible Detection of Proteins/Peptides of Importance in Obesity Research (U01 Clinical Trial Not Allowed) Apply for RFA DK 19 001 Funding Number: RFA DK 19 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| The KUH Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 Clinical Trial Not Allowed) Apply for RFA DK 18 024 Funding Number: RFA DK 18 024 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Developmental Centers for Interdisciplinary Research in Benign Urology (P20 Clinical Trial Not Allowed) Apply for RFA DK 18 028 Funding Number: RFA DK 18 028 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| George M. O'Brien Urology Cooperative Research Centers Program (U54 Clinical Trial Optional) Apply for RFA DK 18 029 Funding Number: RFA DK 18 029 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Multidisciplinary K12 Urologic Research (KURe) Career Development Program (K12 Clinical Trial Optional) Apply for RFA DK 18 027 Funding Number: RFA DK 18 027 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| High impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional) Apply for PAR 19 202 Funding Number: PAR 19 202 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
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