Comparative Genomics Research Program (R01) | PAR 17 482

Opportunity Information: Apply for PAR 17 482

The Comparative Genomics Research Program (R01) is a National Institutes of Health (NIH) funding opportunity led by the National Human Genome Research Institute (NHGRI) that supports research using comparative genomics to better understand how genomes are built, how they function, and how specific genomic features connect to observable traits (phenotypes). The core idea is that by comparing genomes across a wide range of species, researchers can identify conserved and divergent elements, clarify the biological roles of genes and regulatory regions, and uncover principles of genome organization that help explain mechanisms relevant to human health and disease. In addition to hypothesis-driven biological studies, the program also places clear emphasis on developing new analytical methods, computational tools, and community resources that strengthen the broader comparative genomics field.

The science focus spans two main lanes. One lane funds studies that use multiple species to illuminate basic biological processes with relevance to disease and health, such as interpreting functional elements in the genome, understanding genome evolution and structure, and linking genomic variation to phenotypic differences. This can include work that leverages evolutionary conservation to pinpoint functional regions, uses phylogenetic comparisons to infer function, or employs cross-species models to interpret human genomic findings. The second lane supports tool and resource development, including novel algorithms, statistical approaches, software pipelines, databases, reference resources, and other widely useful assets that help the comparative genomics research community analyze and interpret complex multi-species genomic data more effectively.

Administratively, this opportunity is offered as an NIH R01 research project grant under a discretionary funding category focused on health. The program is identified as Funding Opportunity Title "Comparative Genomics Research Program (R01)" with Funding Opportunity Number PAR-17-482 and CFDA number 93.172. The opportunity was created on September 12, 2017, and the original closing date listed in the source information is January 7, 2021. The provided source data does not specify an award ceiling or the expected number of awards, which typically means applicants would need to consult the full announcement or NIH guidance for budget expectations, scope alignment, and submission details.

Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations and tribal governments that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities. The announcement also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal government agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities, including foreign organizations. Taken together, the eligibility language signals NHGRI's intent to encourage participation from a diverse set of institutions and communities, including those that may bring unique comparative species expertise, specialized data resources, or perspectives that broaden the impact of comparative genomics research.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Comparative Genomics Research Program (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
• This funding opportunity was created on 2017-09-12.
• Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 17 482

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