Opportunity Information: Apply for RFA IP 24 045
The CDC is offering a cooperative agreement to create a coordinated national network of community-based study cohorts that can track how respiratory viruses behave over time and, importantly, be ready to pivot quickly when a new virus or variant appears. The opportunity is rooted in a major lesson from the early COVID-19 response: the United States did not have enough standing, community-level infrastructure to generate real-time evidence on infection risk, transmission patterns, immune protection, and longer-term outcomes. Because launching brand-new studies takes time, CDC had to rely on a patchwork of existing platforms that were originally built for other purposes. That experience showed why hospital-based surveillance is essential for understanding severe disease, but also why community cohorts are critical for capturing the full picture of infection and spread, including mild and asymptomatic cases, viral kinetics, household or community transmission dynamics, and the real-world effects of vaccination and other prevention measures.
This grant aims to establish and sustain multiple cohorts across the country that collectively represent diverse geographies, demographics, and age groups. The target age strata explicitly include children under 5, school-aged children and adolescents ages 5 to 17, adults ages 18 to 64, and older adults over 64. By designing cohorts around these groups and ensuring broader demographic and regional coverage, the network is intended to provide ongoing, comparable data streams that can detect shifts in respiratory virus epidemiology in the post-COVID period. In practical terms, that means being able to monitor changing infection risk, transmission intensity, and patterns of immunity as population behaviors, vaccination coverage, and circulating viruses evolve.
A central theme of the opportunity is consolidation and coordination. Instead of many disconnected projects using different methods, the CDC wants a unified network that can operate more efficiently, reduce duplication, and improve communication and collaboration among sites and with CDC. The expectation is that a standing network will shorten the time between an emerging public health threat and actionable evidence, allowing CDC and partners to rapidly assess who is getting infected, where transmission is occurring, how quickly a virus is spreading, and how well preventive strategies such as vaccination or other interventions are working in real-world community settings. This preparedness function is emphasized as a key advantage: the network should be able to generate timely data not only for known respiratory viruses but also in response to a novel pathogen or a significant new variant.
Administratively, this is a discretionary funding opportunity under a cooperative agreement mechanism, meaning CDC will likely have substantial involvement in coordination, technical input, and expectations around harmonization and shared objectives across awardees. It falls under a health activity category and is managed by the Centers for Disease Control and Prevention (CDC) through ERA. The opportunity number is RFA IP 24 045, listed under CFDA 93.083. The original application closing date was February 20, 2024. The award ceiling is $5,750,000, and CDC anticipates making about 9 awards, indicating an intention to fund multiple cohort sites or organizations that together form the network rather than relying on a single national awardee.
Eligible applicants are broad and include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status, excluding IHEs in those categories); and for-profit organizations other than small businesses. This wide eligibility reflects the reality that effective community cohorts can be housed in many different types of institutions, including universities, health departments, tribal entities, and community-based organizations, and that building a geographically and demographically diverse network often requires flexibility in who can serve as the lead organization.
Overall, the opportunity is essentially about building durable, community-level "listening posts" for respiratory viruses: cohorts that routinely collect specimens and survey information and can quickly scale or adapt their protocols when conditions change. The intended payoff is faster, better evidence during the next respiratory virus surge or pandemic threat, along with a steadier understanding of how infection, immunity, vaccination effects, and longer-term outcomes are changing across the United States between emergencies.Apply for RFA IP 24 045
- The Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Network of Community Cohorts for Monitoring Changes in Respiratory Virus Epidemiology (Pandemic Preparedness Cohorts)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.083.
- This funding opportunity was created on 2023-12-14.
- Applicants must submit their applications by 2024-02-20. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $5,750,000.00 in funding.
- The number of recipients for this funding is limited to 9 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses.
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Frequently Asked Questions (FAQs)
What is this CDC funding opportunity about?
This CDC cooperative agreement aims to create a coordinated national network of community-based study cohorts that can track respiratory viruses over time and quickly pivot when a new virus or variant emerges. The network is intended to generate timely, community-level evidence on infection risk, transmission patterns, immune protection, vaccination and prevention effects, and longer-term outcomes.
Why is CDC investing in community-based cohorts instead of relying only on hospitals and clinics?
The opportunity is based on a key lesson from early COVID-19: the United States did not have enough standing, community-level infrastructure to produce real-time evidence on infection and spread. Hospital-based surveillance is crucial for understanding severe disease, but community cohorts are needed to capture the full picture, including mild and asymptomatic infections, viral kinetics, household and community transmission dynamics, and real-world prevention effects.
What problem is the CDC trying to solve from the early COVID-19 response?
During early COVID-19, launching brand-new studies took too long, so CDC relied on a patchwork of existing platforms that were originally built for other purposes. This opportunity is designed to establish durable, ready-to-use community research infrastructure so evidence can be generated faster when threats emerge.
What is meant by a "coordinated national network" in this grant?
CDC is seeking consolidation and coordination across multiple cohorts and awardees so the network can operate more efficiently, reduce duplication, and improve communication and collaboration among sites and with CDC. The intent is to move away from disconnected projects that use different methods and toward harmonized, comparable data streams.
What kinds of respiratory virus questions is the network supposed to answer?
Based on the description, the network is meant to track how respiratory viruses behave over time and generate evidence on infection risk, transmission intensity, transmission patterns (including household/community spread), immune protection, viral kinetics, the real-world effects of vaccination and other prevention measures, and longer-term outcomes.
Does the network need to be able to respond to new variants or novel pathogens?
Yes. A core expectation is readiness to pivot quickly when a new virus or significant new variant appears. The preparedness function is emphasized as a major advantage of having a standing, coordinated network.
What populations and age groups are expected to be included in the cohorts?
The opportunity explicitly targets coverage across these age strata: children under 5, school-aged children and adolescents ages 5 to 17, adults ages 18 to 64, and older adults over 64. Cohorts are intended to collectively represent diverse geographies, demographics, and age groups.
Is diversity of geography and demographics an expectation?
Yes. The grant aims to establish and sustain multiple cohorts across the country that collectively represent diverse geographies and demographics, along with the specified age strata.
What is the practical value of having comparable data streams across cohorts?
Comparable, ongoing data streams can help detect shifts in respiratory virus epidemiology in the post-COVID period, including changes in infection risk, transmission intensity, and immunity patterns as behaviors, vaccination coverage, and circulating viruses evolve.
What does CDC mean by "standing" community-level infrastructure?
It refers to cohorts that already exist and routinely collect information (such as specimens and survey data) so they can produce evidence quickly, rather than needing to be created from scratch during an emergency.
What kinds of data collection activities are implied for these cohorts?
The description characterizes cohorts as community "listening posts" that routinely collect specimens and survey information, and can scale or adapt protocols when conditions change.
How does this network support public health preparedness?
By shortening the time between an emerging threat and actionable evidence. The network is intended to allow rapid assessment of who is getting infected, where transmission is occurring, how quickly a virus is spreading, and how well prevention strategies (like vaccination or other interventions) are performing in real-world community settings.
What is the funding mechanism for this opportunity?
This is a discretionary funding opportunity under a cooperative agreement mechanism. That generally indicates CDC will have substantial involvement in coordination, technical input, and expectations around harmonization and shared objectives across awardees.
Which agency is managing this opportunity and where is it administered?
The opportunity is managed by the Centers for Disease Control and Prevention (CDC) and is administered through ERA.
What is the opportunity number and CFDA listing?
The opportunity number is RFA IP 24 045, and it is listed under CFDA 93.083.
When was the original application closing date?
The original application closing date was February 20, 2024.
How much funding is available per award?
The award ceiling is $5,750,000.
How many awards does CDC expect to make?
CDC anticipates making about 9 awards, suggesting the intent to fund multiple cohort sites or organizations that together form the national network.
Is this intended to be a single national award or multiple coordinated awards?
Based on the anticipated number of awards (about 9), the opportunity is structured to support multiple awardees that collectively form the network rather than relying on a single national awardee.
Who is eligible to apply?
Eligible applicants include: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status, excluding IHEs in those categories); and for-profit organizations other than small businesses.
Why is eligibility so broad for this program?
The opportunity recognizes that effective community cohorts can be housed in many types of institutions (such as universities, health departments, tribal entities, and community-based organizations). Broad eligibility helps support a geographically and demographically diverse national network.
What is the main goal of consolidating projects into a unified network?
The goal is to reduce duplication, improve efficiency, and strengthen collaboration and communication across sites and with CDC, producing faster and more actionable evidence during surges or emerging threats.
What is the larger public health payoff CDC expects from this investment?
The intended payoff is faster, better evidence during the next respiratory virus surge or pandemic threat, along with a steadier understanding of how infection, immunity, vaccination effects, and longer-term outcomes change across the United States between emergencies.
What is the health activity category referenced in the opportunity?
The opportunity falls under a health activity category and is managed by CDC.
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Applicants who have applied for this opportunity (RFA IP 24 045) also looked into and applied for these:
| Funding Opportunity |
|---|
| Nationwide Cohort to Estimate Burden of Respiratory Viruses and Immunologic Response (Blood Donor Cohort) Apply for RFA IP 24 046 Funding Number: RFA IP 24 046 Agency: Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $4,500,000 |
| Health Promotion and Disease Prevention Research Centers: 2024 Special Interest Project Competitive Supplements (SIPS) Apply for RFA DP 24 062 Funding Number: RFA DP 24 062 Agency: Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $675,000 |
| Strengthening Capacity of Central Asia and Eastern Europe Countries to Implement Sustainable and Effective HIV/AIDS Prevention, Care, and Treatment and Health Security Programs under PEPFAR Apply for CDC RFA GH 24 0069 Funding Number: CDC RFA GH 24 0069 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Screening, Brief Intervention, and Referral to Treatment (SBIRT) Apply for TI 24 010 Funding Number: TI 24 010 Agency: Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $995,000 |
| Clinical and Public Health Curriculum Development, Training, Mentoring, and Implementation of Continuous Quality Improvement for the Haitian Healthcare System under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0071 Funding Number: CDC RFA GH 24 0071 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Building and Improving Integrated Laboratory Capacity and Quality Services in the Democratic Republic of the Congo (DRC) under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0073 Funding Number: CDC RFA GH 24 0073 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Targeted Support for Improving HIV Treatment Continuity, Ensuring Availability of Alternate Secure HIV Drug Delivery Points and Services, and Building Capacity of Communities in Haiti under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0075 Funding Number: CDC RFA GH 24 0075 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Enhance Population Access to Comprehensive HIV/AIDS Services to Achieve HIV/AIDS Epidemic Control in the Democratic Republic of the Congo (DRC), Specifically in Haut-Katanga Province under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0074 Funding Number: CDC RFA GH 24 0074 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Develop, Implement, and Sustain High-Quality Comprehensive Facility and Community-Based HIV 95-95-95 Cascade Activities for Children, Adolescents, and Adults in Cameroon under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0092 Funding Number: CDC RFA GH 24 0092 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening the Government of Lesotho’s National and District HIV and TB Programming through Advancing Health Information Systems, Case-Based Surveillance, Monitoring, Evaluation and Quality Improvement Support under PEPFAR Apply for CDC RFA GH 24 0090 Funding Number: CDC RFA GH 24 0090 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Improving Integrated Surveillance Methods and Quality of Public Health Systems to Address HIV in Jamaica and Trinidad & Tobago under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0101 Funding Number: CDC RFA GH 24 0101 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Enhance Population Access to Comprehensive HIV/AIDS Services to Achieve HIV/AIDS Epidemic Control in the Democratic Republic of the Congo (DRC), Specifically in Kinshasa Province under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0102 Funding Number: CDC RFA GH 24 0102 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening Local and Government Capacity in Mozambique Through Technical Assistance and HIV Service Delivery Support in Zambézia Province in Addition to Targeted National Health Information Systems Strengthening under PEPFAR Apply for CDC RFA GH 24 0099 Funding Number: CDC RFA GH 24 0099 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Integrated Data Management and Analysis for Informed Public Health Decision-Making in Ukraine under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0093 Funding Number: CDC RFA GH 24 0093 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening Laboratory Capacity and Quality for HIV Diagnosis, Care, Treatment, and Monitoring in Malawi under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0097 Funding Number: CDC RFA GH 24 0097 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Implementing Evidence-Based Prevention Interventions for Key and Priority Populations in the Republic of Rwanda under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0098 Funding Number: CDC RFA GH 24 0098 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Enhancing HIV Prevention, Care and Treatment Services through Patient Empowerment, Community Engagement and Improved Public Health Information Systems in Ukraine under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0094 Funding Number: CDC RFA GH 24 0094 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening Mozambique’s Capacity to Integrate and Sustain High-Quality Laboratory Services and Systems under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 24 0096 Funding Number: CDC RFA GH 24 0096 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Understanding Infant Feeding Preferences, Practices, and Outcomes for Mothers and other Parents with HIV in the United States Apply for RFA PS 24 040 Funding Number: RFA PS 24 040 Agency: Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $1,000,000 |
| Improving the Quality of Life of People with HIV Aged 50 Years and Older in the United States Apply for RFA PS 24 039 Funding Number: RFA PS 24 039 Agency: Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $350,000 |
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