Opportunity Information: Apply for 72067423RFA00002

USAID is offering a five-year cooperative agreement focused on achieving and sustaining HIV and TB epidemic control in South Africa's Eastern Cape Province through an integrated service delivery approach. The central aim is to help people in the province live longer, healthier lives by strengthening the full HIV/TB response across the care continuum, from prevention and diagnosis through treatment, retention, and long-term viral suppression, while also addressing TB alongside HIV given their close overlap and shared burden in the region.

The opportunity is designed around three main objectives. First, it seeks to close remaining gaps to HIV epidemic control, which typically means improving how effectively the system finds people who are not yet diagnosed, links them to care quickly, starts them on effective treatment, and keeps them engaged until they reach and maintain viral suppression. Second, it focuses on sustaining health gains by reinforcing the underlying health system, emphasizing stronger, better managed, and more resilient service platforms that can continue delivering results beyond the life of the award. Third, it prioritizes partnerships with communities, civil society organizations, and the private sector to strengthen service delivery and improve client outcomes, recognizing that durable epidemic control depends on more than clinics alone and requires coordinated support in the places where people live.

A defining feature of the activity is its emphasis on a continuum of care that intentionally connects health facilities with community- and household-level services. This includes a particular focus on orphans and other children vulnerable to HIV (often referred to as OVC), meaning the program is expected to support not only clinical HIV-related services, but also the surrounding community-based and household supports that help children and families stay safe, remain engaged in care, and overcome barriers that can lead to treatment interruption or poor outcomes.

Geographically, USAID intends to implement the work in five districts in the Eastern Cape that carry a high HIV/TB burden: Buffalo City Metro, Alfred Nzo District, Amathole District, Chris Hani District, and Oliver Tambo District. The announcement also notes that USAID may adjust the geographic coverage over time based on updated epidemiological information and shifting priorities agreed between the Government of South Africa and the U.S. Government, so applicants should expect an environment where targeting and resource allocation may evolve in response to the data.

From a funding and award structure standpoint, this is a USAID health opportunity (CFDA 98.001) released by USAID South Africa (USAID-Pretoria) under Funding Opportunity Number 72067423RFA00002. It is categorized as "Other" and will be funded through a cooperative agreement, which typically implies substantial involvement by USAID during implementation, such as ongoing technical direction, collaboration on work planning, and adaptive management expectations. USAID anticipates making one award, with an estimated total award amount and ceiling of about USD 75,000,000 for the full five-year period of performance. Eligible applicants are listed broadly as "Others," with details to be clarified in the opportunity's eligibility section, suggesting that a range of organizations may apply depending on the specific requirements in the full solicitation.

Overall, the opportunity funds a single, large-scale implementing partner to coordinate a province-focused HIV/TB response that is integrated across service delivery points, strengthens the health system for long-term durability, and relies on strong community and civil society engagement, with special attention to vulnerable children and households. The overarching expectation is measurable progress toward epidemic control in targeted districts, coupled with a stronger and more resilient platform capable of sustaining those gains over time.

  • The Agency for International Development, South Africa USAID-Pretoria in the health sector is offering a public funding opportunity titled "Achieving and Sustaining HIV/TB Epidemic Control in the Eastern Cape Province – Integrated Service Delivery Response" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001.
  • This funding opportunity was created on Oct 17, 2022.
  • Applicants must submit their applications by Jan 04, 2023 N/A. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $75,000,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for 72067423RFA00002

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Previous opportunity: Notice of Intent to Issue Funding Opportunity Announcement No. DE-FOA-0002823

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